منابع مشابه
Drug–Target Kinetics in Drug Discovery
The development of therapies for the treatment of neurological cancer faces a number of major challenges including the synthesis of small molecule agents that can penetrate the blood-brain barrier (BBB). Given the likelihood that in many cases drug exposure will be lower in the CNS than in systemic circulation, it follows that strategies should be employed that can sustain target engagement at ...
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The impact of target binding kinetics (BK) on the clinical performance of therapeutic agents is presently a topic of intense debate in drug discovery. While retrospective studies suggest that BK is a differentiating parameter in marketed medicines, it is yet unclear how this information could be used to prioritize drug candidates during lead optimization. Motivated by the question whether BK ca...
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Protein misfolding diseases are becoming increasingly prevalent, yet there are very few effective pharmacological treatments. The onset and progression of these diseases is associated with the aberrant aggregation of normally soluble proteins and peptides into amyloid fibrils. Because genetic and physiological findings suggest that protein aggregation is a key event in pathogenesis, an attracti...
متن کاملethnobotany, ethnopharmacology and drug discovery
this manuscript is a review of a number of ethnobotany and ethnopharmacology texts and papers in order to arrive at current understanding and scope of ethnobotany and ethnopharmacology. it includes either a brief definition of both fields and presenting some examples on them. also it has a glimpse on the geographical coverage of research works throughout the world, important issue of property r...
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ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2017
ISSN: 1948-7193,1948-7193
DOI: 10.1021/acschemneuro.7b00185